| 于长江 博士 副教授 硕士生导师 实验室:礼勤楼1022室 Email: yuchj@ahnu.edu.cn |
1. 个人简介:
2012年6月于安徽师范大学硕士研究生毕业后留校工作,2016年6月取得化学博士学位,2018年8月至2020年7月在香港理工大学应用生物与化学科技系做博士后研究。2022年12月,受聘副教授。目前主要从事新型有机功能染料的设计开发、性质及其在能源、材料、生物等领域的应用探索研究。至今以第一作者或通讯作者身份在Angew. Chem. Int. Ed.、Org. Lett.、Mater. Chem. Front.、J. Mater. Chem. C、Chem. Commun.等期刊上发表论文32篇。论文总被引2500余次。
学术研究方向:
1) 多硼氮芳香稠环的合成、性质及应用
2) 异吲哚吡咯染料的合成、性质及应用
科研工作经历:
2012.7 至 今,安徽师范大学,美高梅4858线路登录,硕士生导师
2018.8-2020.7,香港理工大学,应用生物与化学科技系,Postdoctoral Fellow,合作导师:Prof. Wong, Wai-Yeung
学习教育经历:
2013.9–2016.7,安徽师范大学,化学学科专业,博士,导师:焦莉娟 教授
2009.9–2012.6,安徽师范大学,有机化学专业,硕士,导师:焦莉娟 教授
2005.9–2009.7,安徽师范大学,应用化学专业,学士
2. 主持科研项目:
1) 2023年度安徽省高校科研项目,2023AH050149,高稳定高亮近红外二区双并氟硼二叱咯的设计开发与性质研究,2023.9-2026.8,在研
2) 安徽省博士后研究人员科研活动项目,2021B533,高性能双硼肼桥联水杨酰腙吡咯荧光团的合成、性质及应用研究,2021.11-2023.11,在研
3) 安徽省自然科学青年基金项目,2008085QB67,新型立体扭曲双硼肼桥联水杨酰腙吡咯荧光团的设计合成、光学性质及自组装研究,2020.7-2022.6,已结题
4) 南京大学配位化学国家重点实验室开放基金,SKLCC1911,近红外二区AIE 型苯并四吡咯配合物的合成、性质及成像研究,2019.2-2021.1,已结题
5) 安徽师范大学博士启动基金,2017XJJ28,肼桥联吡咯类氟硼荧光染料的合成及性能研究,2017.5–2020.5,已结题
6) 国家自然科学基金青年基金项目,21402001,新型α,β位稠环Aza-BODIPY近红外染料的合成及性能研究,2015.1–2017.12,已结题
3. 实验室人员:
在读硕士生:
在读本科生:2023年创新实验-汪城、林昕、李涵琼、杨梦雪; 毕业设计-石深、石剑、项定睿、高育恒等
已毕业研究生:方兴宝(上海药明康德)、程超(南京药石科技)
4. 代表论文:
7) Yu, C.;* Sun, Y.; Wu, Q.; Shi, Y.; Jiao, L.; Guo, X.; Li J.;* Li, J.;* Hao, E.* Synthesis, properties, and semiconducting characteristics of bisbenzothieno[b]-fused BODIPYs. J. Org. Chem. 2023, DOI: 1.01021/acs.joc.3c01186.
8) Zhao, X.; Hu, B.; Zhou, Q.; Yu, Y.; Hao, E.; Guo, X,; Xu, Y.;* Yu, C.;* Sun, K.;* Lalevée, J.* Triphenylamine-substituted BODIPY dye based photoinitiators for free radical and cationic photopolymerization under visible LED irradiation and application in 3D printing. Dyes Pigments 2023, 111880. DOI: 10.1016/j.dyepig.2023.111880.
9) Yu, C.;* Sun, Y.; Jiao, L.; Hao, E.* Recent advances of highly fluorescent hydrazine inserted pyrrole-based bisboron-anchoring fluorophores: Synthesis and properties. Syn. Lett. 2023, DOI: 10.1055/a-2045-2369.
10) Yu, C.;* Sun, Y.; Fang, X.; Li, J.;* Wu, Q.; Bu, W.; Guo, X.; Wang, H.; Jiao, L.; Hao, E.* Aromatic-ring-fused BOPPY fluorophores: Synthesis, spectral, redox properties, and bioimaging application. Inorg. Chem. 2022, 61, 16718. DOI: 10.1021/acs.inorgchem.2c02517.
11) Yu, C.;* Fang, X.; Wu, Q.; Chen, N.; Cheng, C.; Guo, X.; Hao, E.*; Jiao, L.* Synthesis and spectral properties of aggregation-induced emission-active push-pull chromophores based on isoindole scaffolds. Org. Lett. 2022, 24, 4557. DOI: 10.1021/acs.orglett.2c01659.
12) 于长江;* 程超; 郝二红; 焦莉娟.* 芳并氮杂氟硼二吡咯的合成与应用. 《中国科学:化学》, 2022, 52, 1371. DOI: 10.1360/SSC-2022-0045.
13) Yu, C.;* Guo, X,; Fang, X.; Chen, Na; Wu, Q.; Hao, E.; Jiao, L.* Efficiently emissive, strongly slvatochromic and lipid droplet-specific, fluorescent probes for mapping polarity in vitro. Dyes Pigments 2022, 197, 109838. DOI: 10.1016/j.dyepig.2021.109838.
14) Yu, C.;* Fang, X.; Wang, H.; Guo, X,; Sun, L.; Wu, Q.; Jiao, L.; Hao, E.* A family of highly fluorescent and membrane-permeable bis(BF2) acyl-pyridinylhydrazine dyes with strong solid-state emission and large Stokes shifts: The BOAPH fluorophores. J. Org. Chem. 2021, 86, 11492. https://pubs.acs.org/doi/full/10.1021/acs.joc.1c01042
15) Guo, X.; Tang, B.; Wu, H.; Wu, Q.; Xie, Z.; Yu, C.;* Hao, E.; Jiao, L.* Bright near-infrared a-tetraphenyletheneBODIPY nanoprobes with high aggregated state emission quantum yields in aqueous system for lipid droplet-specific imaging. Mater. Chem. Front. 2021, 5, 3664. https://pubs.rsc.org/en/content/articlelanding/2021/qm/d1qm00067e/unauth
16) Zhao, Y.; Zhao, Y.; Yu, C.;* Liu, S.; Liu, Y.; Hao, E.;* Jiao, L.; Xu, X.; Zhang, Z.;* Li, J.* A novel family of non-symmetric benzothieno[7,6-b]-fused BODIPYs: Synthesis, structures, photophysical properties and lipid droplet-specific imaging in vitro. Dyes Pigments 2021, 196, 109748. https://www.sciencedirect.com/science/article/pii/S0143720821006148
17) Yu, C.; Fang, X.; Wu, Q.; Jiao, L.*; Sun, L.; Li, Z.; So, P.-K.; Wong, W.-Y.*; Hao, E.* A family of BODIPY-like, highly fluorescent and unsymmetrical Bis(BF2) pyrrolyl-acylhydrazone chromophore: BOAPY, Org. Lett. 2020, 22, 4588. DOI: 10.1021/acs.orglett.0c00940
18) Wu, H.; Guo, X.; Yu, C.;* Wong, W.-Y.; Hao, E.; Jiao, L.* Highly photostable ketopyrrolyl-BODIPYs with red aggregation-induced emission characteristics for ultrafast wash-free mitochondria-targeted bioimaging. Dyes Pigments 2020, 176, 108209. https://www.sciencedirect.com/science/article/pii/S0143720819329304
19) Yu, Y.; Yu, C.;* Wu, Q.; Wang, H.; Jiao, L.; Wong, W.-Y.; Hao, E.* Pure E/Z isomers of N-methylpyrrole-benzohydrazide-based BF2 complexes: Remarkable Aggregation-, crystallization-induced emission switching properties and application in sensing intracellular pH microenvironment. J. Mater. Chem. C 2019, 7, 4533. https://pubs.rsc.org/en/content/articlehtml/2019/tc/c9tc00473d
20) Yu, C.; Hao, E.;* Fang, X.; Wu, Q.; Wang, L.; Li, J.; Xu, L.; Jiao, L.;* Wong, W.-Y.* AIE-active difluoroboronated acyl hydrazone dyes (BOAHY) emitting across the entire visible region and their photo-switching properties. J. Mater. Chem. C 2019, 7, 3269. https://pubs.rsc.org/en/content/articlehtml/2019/tc/c9tc00316a
21) Yu, C.;+ Huang, Z.;+ Gu, W.; Wu, Q.; Hao, E.;* Xiao, Y.;* Jiao, L.;* Wong, W.-Y.* A novel family of AIE-active Meso-2-ketopyrrolylBODIPYs: Bright solid-state red fluorescence, morphological properties, and application as viscosimeters in live cells. Mater. Chem. Front. 2019, 3, 1823. https://pubs.rsc.org/en/content/articlehtml/2019/qm/c9qm00154a
22) Yu, Y.; Yu, C.;* Wu, Q.; Wang, H.; Jiao, L.; Wong, W.-Y.; Hao, E.* Pure E/Z isomers of N-methylpyrrole-benzohydrazide-based BF2 complexes: Remarkable Aggregation-, crystallization-induced emission switching properties and application in sensing intracellular pH microenvironment. J. Mater. Chem. C 2019, 7, 4533. https://pubs.rsc.org/en/content/articlehtml/2019/tc/c9tc00473d
23) Yu, C.; Huang, Z.; Wang, X.; Miao, W.; Wu, Q.; Wong, W.-Y.; Hao, E.;* Xiao, Y.;* Jiao L.* A family of highly fluorescent and unsymmetric Bis(BF2) chromophore containing both pyrrole and N-heteroarene derivatives: BOPPY. Org. Lett. 2018, 20, 4462. A Family of Highly Fluorescent and Unsymmetric Bis(BF2) Chromophore Containing Both Pyrrole and N-Heteroarene Derivatives: BOPPY | Organic Letters (acs.org)
24) Yu, C.;* Li, T.; Wu, Q.; Hu, W.; Hao, E.; Jiao, L.* Synthesis structural and spectroscopic properties of quinoxaline-bridged bisBODIPYs. J. Porphyrins Phthalocyanines 2018, 22, 899. https://www.worldscientific.com/doi/abs/10.1142/S1088424618500797
25) Lv, X.; Li, T.; Wu, Q.; Yu, C.;* Jiao, L.; Hao, E.* Polybrominated BOPHY dyes: synthesis, reactivity, and properties. J. Org. Chem. 2018, 83, 1134. https://pubs.acs.org/doi/full/10.1021/acs.joc.7b02415
26) Yu, C.;* Miao, W.; Wang, J.; Hao, E.; Jiao, L.* PyrrolylBODIPYs: syntheses, properties, and application as environment-sensitive fluorescence probes. ACS Omega 2017, 2, 3551. https://pubs.acs.org/doi/full/10.1021/acsomega.7b00444
27) Cui, J.; Sheng, W.; Wu, Q.; Yu, C.;* Hao, E.; Bobadova-Parvanova, P.;* Storer, M.; Asiri, A. M.; Marwani, H. M.; Jiao, L.* Synthesis, structure, and properties of near-infrared [b]phenanthrene-fused BF2 azadipyrromethenes. Chem. Asian J. 2017, 12, 2486. (Very Important Paper) https://onlinelibrary.wiley.com/doi/abs/10.1002/asia.201700876
28) Yu, C.; Wu, Q.; Wang, J.; Wei, Y.; Hao, E.;* Jiao, L.* Red to near-infrared isoindole BODIPY fluorophores: synthesis, crystal structures, spectroscopic and electrochemical properties. J. Org. Chem. 2016, 81, 3761. https://pubs.acs.org/doi/full/10.1021/acs.joc.6b00414
29) Yu, C.; Wu, Q.; Wang, J.; Tian, Z.; Hao, E.;* Jiao, L.* Synthesis and photophysical properties of meso-aryloxy linked BODIPY monomers, dimers, and trimer. J. Porphyrins Phthalocyanines 2016, 20, 475. https://www.worldscientific.com/doi/abs/10.1142/S1088424616500309
30) Li, T.; Gu, W.; Yu, C.;* Lv, X.; Wang, H.; Hao, E.; Jiao, L.* Syntheses and photophysical properties of meso-phenylene bridged boron dipyrromethene monomers, dimers and trimer. Chin. J. Chem. 2016, 34, 989. https://onlinelibrary.wiley.com/doi/abs/10.1002/cjoc.201600500
31) Yu, C.; Jiao, L.;* Li, T.; Wu, Q.; Miao, W.; Wang, J.; Wei, Y.; Mu, X.; Hao, E.* Fusion and planarization of bisBODIPY: a new family of photostable near-infrared dyes. Chem. Commun. 2015, 51, 16852. https://pubs.rsc.org/en/content/articlehtml/2015/cc/c5cc07304a
32) Yu, C.; Hao, E.;* Li, T.; Wang, J.; Sheng, W.; Wei, Y.; Mu, X.; Jiao, L.* Dipyrrolylquinoxaline difluoroborates with intense red solid-state fluorescence. Dalton Trans. 2015, 44, 13897. (Hot Article) https://pubs.rsc.org/en/content/articlehtml/2015/dt/c5dt02012c
33) Yu, C.; Jiao, L.;* Zhang, P.; Feng, Z.; Cheng, C.; Wei, Y.; Mu, X. and Hao, E.* Highly fluorescent BF2 complexes of hydrazine-Schiff base linked bispyrrole, Org. Lett. 2014, 16, 3048. https://pubs.acs.org/doi/full/10.1021/ol501162f
34) Yu, C.; Jiao, L.; Hao, E. Research progress of functional modification of borondipyrromethene (BODIPY) fluorescent dyes. China Science paper 2013, 8, 1291. (in Chinese) http://www.paper.edu.cn/releasepaper/content/201301-1053/
35) Yu, C.; Jiao, L.;* Tan, X.; Wang, J.; Xu, Y.; Wu, Y.; Yang, G.; Wang, Z.; Hao, E.* Straightforward acid-catalyzed synthesis of pyrrolyldipyrromethenes. Angew. Chem. Int. Ed. 2012, 51, 7688. https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201202850
36) Yu, C.; Xu, Y.; Jiao, L.;* Zhou, J.; Wang, Z.; Hao, E.* Isoindole-BODIPY dyes as red to near-infrared fluorophores. Chem. Eur. J. 2012, 18, 6437. https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/chem.201200398
37) Yu, C.; Jiao, L.;* Yin, H.; Zhou, Z.; Pang, W.; Wu, Y.; Wang, Z.; Yang, G.; Hao, E. α-/β-formylated borondipyrrin (BODIPY) dyes: regioselective syntheses and photophysical properties. Eur. J. Org. Chem. 2011, 28, 5460. https://wiley.com/doi/full/10.1002/ejoc.201100736
38) Jiao, L.;* Yu, C.; Wang, J.; Briggs, E. A.; Besley, A. L.; Robinson, D.; Ruedas-Rama, M. J.; Orte, A.; Crovetto, L.; Talavera, E. M.; Alvarez-Pez, J. M.; Van der Auweraer, M.; Boens, N. Unusual Spectroscopic and Photophysical Properties of meso-tert-ButylBODIPY in Comparison to Related Alkylated BODIPY Dyes. RSC Adv. 2015, 5, 89375.
39) Jiao, L.;* Yu, C.; Liu, M.; Wu, Y.; Cong, K.; Meng, T.; Wang, Y.; Hao, E. Synthesis and functionalization of asymmetrical benzo-fused BODIPY dyes. J. Org. Chem. 2010, 75, 6035.
40) Jiao, L.;* Yu, C.; Uppal, T.; Liu, M.; Li, Y.; Zhou, Y.; Hao, E.; Hu, X.; Vicente, M. G. H.* Long-wavelength red fluorescent dyes from 3,5-diiodo-BODIPYs. Org. Biomol. Chem. 2010, 8, 2517.
41) Jiao, L.;* Yu, C.; Li, J.; Wang, Z.; Wu, M.; Hao, E. β-FormylBODIPYs from Vilsmeyer-Haack Reaction. J. Org. Chem. 2009, 74, 7525.
42) Li, Z.; Zhang, L.; Wu, Q.; Li, H.; Kang, Z.; Yu, C.; Hao, E.*; Jiao, L.* Boron-Templated Synthesis of B(III)-Submonoazaporphyrins: The Hybrids of B(III)-Subporphyrins and B(III)-Subporphyrazines. J. Am. Chem. Soc. 2022, 144, 6692. https://pubs.acs.org/doi/full/10.1021/jacs.2c01671
5. 授权专利:
1) 于长江,郝二宏,焦莉娟,黄维扬,异吲哚四吡咯色素及其制备方法, 中国发明专利,授权专利号:ZL 201911273748.8.
2) 于长江,张子瑜,焦莉娟,郝二红,苯并二吡咯酮氟硼荧光染料及其制备方法, 中国发明专利,授权专利号:ZL201911274610.X.
3) 于长江,郝二红,焦莉娟,黄维扬,酰基吡啶肼双氟硼强荧光染料及其制备方法, 中国发明专利,授权专利号:ZL201811258192.0.
4) 于长江,郝二红,焦莉娟,黄维扬,meso-吡咯酮BODIPY染料粘度探针及其制备方法和应用, 中国发明专利,授权专利号:ZL201811258191.6.
5) 于长江,郝二红,焦莉娟,黄维扬,吡咯吡啶肼双氟硼荧光染料及其制备方法和应用,中国发明专利,授权专利号:ZL201810499299.8.
6) 黄维扬,于长江,双异吲哚铱(III)配合物及其制备方法,中国发明专利,授权专利号:ZL202010160840.X.
7) 焦莉娟,于长江,吴昊,郝二红,氟硼荧光探针在线粒体定位中的应用,中国发明专利,授权专利号:ZL202010039832.X.
8) 郝二红,于长江,焦莉娟,黄维扬,线性共轭异吲哚多吡咯色素及其制备方法,中国发明专利,授权专利号:CN201911275827.2.
9) 郝二红,于长江,张年荣,焦莉娟,一类吡咯腙肼双氟硼荧光染料及其制备方法,中国发明专利,授权专利号:CN201810499260.6.